Corticotropin-releasing hormone augments natural killer cell activity through a naloxone-sensitive pathway
DJJ Carr, BR DeCosta, AE Jacobson, KC Rice… - Journal of …, 1990 - Elsevier
Overnight treatment of murine leukocytes with corticotropin-releasing hormone (CRH) and
arginine vasopressin enhances natural killer cell activity. Moreover, the opioid receptor
antagonist, naloxone, as well as the delta-class opioid receptor antagonist, naltrindole, can
block this effect. The responsivity of murine leukocytes to CRH is both dose-and time-
dependent. The effector cells are both MAC-1 and Thy-1.2 antigen-positive. Whereas β-
endorphin is also shown to enhance natural killer cell activity in a naloxone-reversible …
arginine vasopressin enhances natural killer cell activity. Moreover, the opioid receptor
antagonist, naloxone, as well as the delta-class opioid receptor antagonist, naltrindole, can
block this effect. The responsivity of murine leukocytes to CRH is both dose-and time-
dependent. The effector cells are both MAC-1 and Thy-1.2 antigen-positive. Whereas β-
endorphin is also shown to enhance natural killer cell activity in a naloxone-reversible …