The β-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid
In this study we show that the opioid peptide β-endorphin exerts a tonic inhibitory effect on
the proliferative response of splenocytes to the polyclonal mitogen phytohemoagglutinin
throughout two separate sites of action: one central and one peripheral. The
intracerebroventricular administration of β-endorphin, in fact, induces a significant inhibition
of splenocyte proliferation. In contrast, both the intracerebroventricular and the peripheral
administration of anti-β-endorphin γ globulins induce a significant increase in proliferation …
the proliferative response of splenocytes to the polyclonal mitogen phytohemoagglutinin
throughout two separate sites of action: one central and one peripheral. The
intracerebroventricular administration of β-endorphin, in fact, induces a significant inhibition
of splenocyte proliferation. In contrast, both the intracerebroventricular and the peripheral
administration of anti-β-endorphin γ globulins induce a significant increase in proliferation …