[HTML][HTML] Dopamine-induced endocytosis of Na+, K+-ATPase is initiated by phosphorylation of Ser-18 in the rat α subunit and is responsible for the decreased activity in …
AV Chibalin, G Ogimoto, CH Pedemonte… - Journal of Biological …, 1999 - ASBMB
Dopamine inhibits Na+, K+-ATPase activity in renal tubule cells. This inhibition is associated
with phosphorylation and internalization of the α subunit, both events being protein kinase C-
dependent. Studies of purified preparations, fusion proteins with site-directed mutagenesis,
and heterologous expression systems have identified two major protein kinase C
phosphorylation residues (Ser-11 and Ser-18) in the rat α 1 subunit isoform. To identify the
phosphorylation site (s) that mediates endocytosis of the subunit in response to dopamine …
with phosphorylation and internalization of the α subunit, both events being protein kinase C-
dependent. Studies of purified preparations, fusion proteins with site-directed mutagenesis,
and heterologous expression systems have identified two major protein kinase C
phosphorylation residues (Ser-11 and Ser-18) in the rat α 1 subunit isoform. To identify the
phosphorylation site (s) that mediates endocytosis of the subunit in response to dopamine …