Vitamin D and calcium-sensing receptor genotypes in men and premenopausal women with low bone mineral density
M Eckstein, I Vered, S Ish-Shalom, AB Shlomo… - IMAJ-RAMAT GAN …, 2002 - ima.org.il
Background: Genetic factors have been shown to play a major role in the development of
peak bone mass, with hereditability accounting for about 50-85% of the variance in bone
mass. Numerous candidate genes were proposed to be involved in osteoporosis, but the
precise genes and their relative contribution remain unknown. Objectives: To gain insight
into the genetic basis of idiopathic low bone mineral density in Israeli patients by analyzing
the impact of two candidate genes: polymorphism of the vitamin D receptor gene and …
peak bone mass, with hereditability accounting for about 50-85% of the variance in bone
mass. Numerous candidate genes were proposed to be involved in osteoporosis, but the
precise genes and their relative contribution remain unknown. Objectives: To gain insight
into the genetic basis of idiopathic low bone mineral density in Israeli patients by analyzing
the impact of two candidate genes: polymorphism of the vitamin D receptor gene and …
