Induction of differentiation in cultured rat and human podocytes.
P Mundel, J Reiser, W Kriz - Journal of the American Society of …, 1997 - journals.lww.com
Mature podocytes are highly differentiated cells that are unable to divide in vivo. During
glomerulogenesis, podocytes develop from simple cuboidal cells into their adult phenotype,
which is characterized by a complex pattern of processes. Cultivation of podocytes under
standard conditions leads to dedifferentiation, including the loss of processes and of pp44, a
marker of differentiated podocytes. In this study, the cell culture conditions for rat and human
podocytes were modified by avoiding repeated subcultivation. This led to profound …
glomerulogenesis, podocytes develop from simple cuboidal cells into their adult phenotype,
which is characterized by a complex pattern of processes. Cultivation of podocytes under
standard conditions leads to dedifferentiation, including the loss of processes and of pp44, a
marker of differentiated podocytes. In this study, the cell culture conditions for rat and human
podocytes were modified by avoiding repeated subcultivation. This led to profound …