[HTML][HTML] Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and tumor necrosis factor-mediated …
RB Kimble, S Srivastava, FP Ross, A Matayoshi… - Journal of Biological …, 1996 - ASBMB
To analyze how estrogen blocks osteoclastogenesis, we investigated the effects of
ovariectomy on osteoclast (OC) formation in co-cultures of purified OC precursors and
purified stromal cells (SC). OC formation was higher in co-cultures containing SC from
ovariectomized mice than in those containing SC from sham-operated mice, thus suggesting
that estrogen regulates osteoclastogenesis by targeting SC. Ovariectomy also increased the
mononuclear cell secretion of interleukin (IL)-1) and tumor necrosis factor (TNF) and the SC …
ovariectomy on osteoclast (OC) formation in co-cultures of purified OC precursors and
purified stromal cells (SC). OC formation was higher in co-cultures containing SC from
ovariectomized mice than in those containing SC from sham-operated mice, thus suggesting
that estrogen regulates osteoclastogenesis by targeting SC. Ovariectomy also increased the
mononuclear cell secretion of interleukin (IL)-1) and tumor necrosis factor (TNF) and the SC …