Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents …
JW Yewdell, CC Norbury, JR Bennink - Advances in immunology, 1999 - Elsevier
Publisher Summary Most cell types in the body constitutively express class I molecules that
present thousands of distinct peptides from a diverse array of housekeeping and
differentiation-specific cellular proteins. Under normal circumstances, these peptides fail to
activate T CD8+ either because of the absence of T CD8+ bearing a complementary T cell
receptor (TCR) or the silencing of such autoreactive T CD8+ in the thymus or periphery. The
MHC class I system evolves to identify cells bearing foreign peptides that in the natural world …
present thousands of distinct peptides from a diverse array of housekeeping and
differentiation-specific cellular proteins. Under normal circumstances, these peptides fail to
activate T CD8+ either because of the absence of T CD8+ bearing a complementary T cell
receptor (TCR) or the silencing of such autoreactive T CD8+ in the thymus or periphery. The
MHC class I system evolves to identify cells bearing foreign peptides that in the natural world …