Neurotransmitter release, hormone secretion and a variety of other secretory process are
tightly regulated with exocytotic fusion of secretory vesicles being triggered by a rise in
cytosolic Ca2+ concentration. A series of proteins that act as part of a conserved core
machinery for vesicle docking and fusion throughout the cell have been identified. In
regulated exocytosis this core machinery must be controlled by Ca2+-sensor proteins that
allow rapid activation of the fusion process following elevation of cytosolic Ca2+ …