Cytokine production by CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis in mice
Zwilling - Clinical & Experimental Immunology, 1998 - Wiley Online Library
Zwilling
Clinical & Experimental Immunology, 1998•Wiley Online LibraryChanges in the pattern of cytokines found in CD4 and CD8 T cells during the growth of
Mycobacterium tuberculosis that resulted in the establishment of a latent infection were
monitored. Subsets of T cells were identified based on their differential expression of CD45
and CD44 which allowed them to be classified as naive, activated or memory. We found that
the T cells in the lung produced a predominantly type 1 cytokine response. The appearance
of large numbers of Th1 cells coincided with the establishment of latency. In contrast, the …
Mycobacterium tuberculosis that resulted in the establishment of a latent infection were
monitored. Subsets of T cells were identified based on their differential expression of CD45
and CD44 which allowed them to be classified as naive, activated or memory. We found that
the T cells in the lung produced a predominantly type 1 cytokine response. The appearance
of large numbers of Th1 cells coincided with the establishment of latency. In contrast, the …
Changes in the pattern of cytokines found in CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis that resulted in the establishment of a latent infection were monitored. Subsets of T cells were identified based on their differential expression of CD45 and CD44 which allowed them to be classified as naive, activated or memory. We found that the T cells in the lung produced a predominantly type 1 cytokine response. The appearance of large numbers of Th1 cells coincided with the establishment of latency. In contrast, the predominant response in the mediastinal lymph node and spleen was a Th2‐type response.
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