[HTML][HTML] Gamma-Interferon-inducibleLysosomal Thiol Reductase (GILT): Maturation, activity, and mechanism of action
UT Phan, B Arunachalam, P Cresswell - Journal of Biological Chemistry, 2000 - ASBMB
We recently identified agamma-interferon-induciblelysosomal thiol reductase (GILT),
constitutively expressed in antigen-presenting cells, that catalyzes disulfide bond reduction
both in vitro andin vivo and is optimally active at acidic pH. GILT is synthesized as a 35-kDa
precursor, and following delivery to major histocompatibility complex (MHC) class II-
containing compartments (MIICs), is processed to the mature 30-kDa form via cleavage of N-
and C-terminal propeptides. The generation of MHC class II epitopes requires both protein …
constitutively expressed in antigen-presenting cells, that catalyzes disulfide bond reduction
both in vitro andin vivo and is optimally active at acidic pH. GILT is synthesized as a 35-kDa
precursor, and following delivery to major histocompatibility complex (MHC) class II-
containing compartments (MIICs), is processed to the mature 30-kDa form via cleavage of N-
and C-terminal propeptides. The generation of MHC class II epitopes requires both protein …