[HTML][HTML] FER kinase activation of Stat3 is determined by the N-terminal sequence
S Priel-Halachmi, I Ben-Dor, S Shpungin… - Journal of Biological …, 2000 - ASBMB
p94 fer and p51 ferT are two tyrosine kinases that share identical SH2 and kinase domains
but differ in their N-terminal regions. To further explore the cellular functions of these two
highly related tyrosine kinases, their subcellular distribution profiles and in
vivophosphorylation activity were followed using double immunofluorescence assay. When
combined with immunoprecipitation analysis, this assay showed that p94 fer can lead to the
tyrosine phosphorylation and activation of Stat3 but not of Stat1 or Stat2. Native p94 fer …
but differ in their N-terminal regions. To further explore the cellular functions of these two
highly related tyrosine kinases, their subcellular distribution profiles and in
vivophosphorylation activity were followed using double immunofluorescence assay. When
combined with immunoprecipitation analysis, this assay showed that p94 fer can lead to the
tyrosine phosphorylation and activation of Stat3 but not of Stat1 or Stat2. Native p94 fer …