Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy
AP Mizisin, GD Shelton, S Wagner, C Rusbridge… - Acta …, 1998 - Springer
AP Mizisin, GD Shelton, S Wagner, C Rusbridge, HC Powell
Acta neuropathologica, 1998•SpringerNerve biopsy samples from two cats with spontaneously occurring diabetes were examined.
The predominant nerve fiber abnormalities observed were restricted to the myelin sheath
and Schwann cell. Reactive, degenerative and proliferative Schwann cell changes were
evident but the most striking abnormality encountered was splitting and ballooning of the
myelin sheath. These observations highlight the significance of Schwann cell injury in the
pathogenesis of diabetic neuropathy.
The predominant nerve fiber abnormalities observed were restricted to the myelin sheath
and Schwann cell. Reactive, degenerative and proliferative Schwann cell changes were
evident but the most striking abnormality encountered was splitting and ballooning of the
myelin sheath. These observations highlight the significance of Schwann cell injury in the
pathogenesis of diabetic neuropathy.
Abstract
Nerve biopsy samples from two cats with spontaneously occurring diabetes were examined. The predominant nerve fiber abnormalities observed were restricted to the myelin sheath and Schwann cell. Reactive, degenerative and proliferative Schwann cell changes were evident but the most striking abnormality encountered was splitting and ballooning of the myelin sheath. These observations highlight the significance of Schwann cell injury in the pathogenesis of diabetic neuropathy.
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