[HTML][HTML] Expressional patterns of cytokines in a murine model of acute myocarditis: early expression of cardiotrophin-1

M Okuno, M Nakagawa, M Shimada, M Saito… - Laboratory …, 2000 - Elsevier
To determine the role of cytokines in acute myocarditis, we examined expressional patterns
of cardiotrophin-1 (CT-1), TNF-α, and IL-1α in a murine model of acute myocarditis. Ten-day-
old Institute of Cancer Research mice were injected with Coxsackievirus B3 and killed on
Days 1, 2, 3, 4, 5, 7, 10, 14, and 28 of injection. TNF-α and IL-1α expressions were
investigated on histological sections from each heart, and mRNA expression of TNF-α, IL-1α,
and CT-1 in the heart was examined by reverse transcription-polymerase chain reaction and …