Signal for attachment of a phospholipid membrane anchor in decay accelerating factor
IW Caras, GN Weddell, MA Davitz, V Nussenzweig… - Science, 1987 - science.org
IW Caras, GN Weddell, MA Davitz, V Nussenzweig, DW Martin Jr
Science, 1987•science.orgDecay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored
to the cell surface by a glycophospholipid membrane anchor that is covalently attached to
the carboxyl terminus of the protein. The last 37 amino acids of membrane DAF, when fused
to the carboxyl terminus of a secreted protein, are sufficient to target the fusion protein to the
plasma membrane by means of a glycophospholipid anchor. This approach provides a
novel means of targeting proteins to the cell-surface membrane.
to the cell surface by a glycophospholipid membrane anchor that is covalently attached to
the carboxyl terminus of the protein. The last 37 amino acids of membrane DAF, when fused
to the carboxyl terminus of a secreted protein, are sufficient to target the fusion protein to the
plasma membrane by means of a glycophospholipid anchor. This approach provides a
novel means of targeting proteins to the cell-surface membrane.
Decay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored to the cell surface by a glycophospholipid membrane anchor that is covalently attached to the carboxyl terminus of the protein. The last 37 amino acids of membrane DAF, when fused to the carboxyl terminus of a secreted protein, are sufficient to target the fusion protein to the plasma membrane by means of a glycophospholipid anchor. This approach provides a novel means of targeting proteins to the cell-surface membrane.
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