The role of IL-10 in crossregulation of TH1 and TH2 responses
TR Mosmann, KW Moore - Immunology today, 1991 - cell.com
TR Mosmann, KW Moore
Immunology today, 1991•cell.comThe identification of helper T (TH)-cell subsets has greatly improved understanding of the
regulation of immune effector functions. In addition to controlling humoral and delayed-type
hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory
cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in
particular the role of interleukin 10, a cytokine secreted by TH 2 cells that inhibits TH 1-cell
function.
regulation of immune effector functions. In addition to controlling humoral and delayed-type
hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory
cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in
particular the role of interleukin 10, a cytokine secreted by TH 2 cells that inhibits TH 1-cell
function.
The identification of helper T (TH)-cell subsets has greatly improved understanding of the regulation of immune effector functions. In addition to controlling humoral and delayed-type hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in particular the role of interleukin 10, a cytokine secreted by TH2 cells that inhibits TH1 -cell function.
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