[HTML][HTML] Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages
S Matveev, DR van der Westhuyzen, EJ Smart - Journal of lipid research, 1999 - ASBMB
Scavenger receptor (SR)-BI mediates the selective uptake of high density lipoprotein (HDL)
cholesteryl esters and the efflux of free cholesterol. In Chinese hamster ovary (CHO) cells,
SR-BI is predominantly associated with caveolae which we have recently demonstrated are
the initial loci for membrane transfer of HDL cholesteryl esters. Because cholesterol
accumulation in macrophages is a critical event in atherogenesis, we investigated the
expression of SR-BI and caveolin-1 in several macrophage cell lines. Human THP-1 …
cholesteryl esters and the efflux of free cholesterol. In Chinese hamster ovary (CHO) cells,
SR-BI is predominantly associated with caveolae which we have recently demonstrated are
the initial loci for membrane transfer of HDL cholesteryl esters. Because cholesterol
accumulation in macrophages is a critical event in atherogenesis, we investigated the
expression of SR-BI and caveolin-1 in several macrophage cell lines. Human THP-1 …