[HTML][HTML] Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells (∗)
S Grugel, G Finkenzeller, K Weindel, B Barleon… - Journal of Biological …, 1995 - ASBMB
Stimulation of NIH 3T3 cells with platelet-derived growth factor (PDGF)-BB and 12-O-
tetradecanoylphorbol-13-acetate (TPA) enhances vascular endothelial growth factor (VEGF)
gene expression. To address the question of whether Ras and Raf are involved in the
induction of VEGF gene expression by PDGF and TPA, we examined the effects of both
factors on NIH 3T3 cells stably transfected with v-Ha-ras or v-raf. In serum-starved NIH 3T3
cells, only low levels of mRNA expression can be detected, whereas both ras and raf …
tetradecanoylphorbol-13-acetate (TPA) enhances vascular endothelial growth factor (VEGF)
gene expression. To address the question of whether Ras and Raf are involved in the
induction of VEGF gene expression by PDGF and TPA, we examined the effects of both
factors on NIH 3T3 cells stably transfected with v-Ha-ras or v-raf. In serum-starved NIH 3T3
cells, only low levels of mRNA expression can be detected, whereas both ras and raf …