Increased 8,12‐iso‐iPF2α‐VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity
Annals of neurology, 2000•Wiley Online Library
Abstract The isoprostane 8, 12‐iso‐iPF2α‐VI is a sensitive and specific marker of in vivo
lipid peroxidation. We found elevated levels in the urine, blood, and cerebrospinal fluid of
patients with Alzheimer's disease (AD) that correlated with measures of cognitive and
functional impairment, established biomarkers of AD pathology (cerebrospinal fluid tau and
amyloid) and the number of apolipoprotein E ε4 alleles. These results suggest that 8, 12‐iso‐
iPF2α‐VI is a useful biomarker of oxidative damage in AD. Ann Neurol 2000; 48: 809–812
lipid peroxidation. We found elevated levels in the urine, blood, and cerebrospinal fluid of
patients with Alzheimer's disease (AD) that correlated with measures of cognitive and
functional impairment, established biomarkers of AD pathology (cerebrospinal fluid tau and
amyloid) and the number of apolipoprotein E ε4 alleles. These results suggest that 8, 12‐iso‐
iPF2α‐VI is a useful biomarker of oxidative damage in AD. Ann Neurol 2000; 48: 809–812
Abstract
The isoprostane 8,12‐iso‐iPF2α‐VI is a sensitive and specific marker of in vivo lipid peroxidation. We found elevated levels in the urine, blood, and cerebrospinal fluid of patients with Alzheimer's disease (AD) that correlated with measures of cognitive and functional impairment, established biomarkers of AD pathology (cerebrospinal fluid tau and amyloid) and the number of apolipoprotein E ε4 alleles. These results suggest that 8,12‐iso‐iPF2α‐VI is a useful biomarker of oxidative damage in AD. Ann Neurol 2000;48:809–812
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