Alzheimer's disease, the major dementing disorder of the elderly that affects over 4 million
Americans, is related to amyloid β-peptide, the principal component of senile plaques in
Alzheimer's disease brain. Oxidative stress, manifested by protein oxidation and lipid
peroxidation, among other alterations, is a characteristic of Alzheimer's disease brain. Our
laboratory united these two observations in a model to account for neurodegeneration in
Alzheimer's disease brain, the amyloid β-peptide-associated oxidative stress model for …