[HTML][HTML] An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes
MA Íñiguez, S Martı́nez-Martı́nez, C Punzón… - Journal of Biological …, 2000 - ASBMB
We have previously reported that transcriptional induction of cyclooxygenase-2 (COX-2)
isoenzyme occurs early after T cell receptor triggering, suggesting functional implications of
cyclooxygenase activity in this process. Here, we identify the cis-acting elements
responsible for the transcriptional activation of this gene in human T lymphocytes. COX-2
promoter activity was induced upon T cell activation both in primary resting T lymphocytes
and in Jurkat cells. This induction was abrogated by inhibition of calcineurin phosphatase …
isoenzyme occurs early after T cell receptor triggering, suggesting functional implications of
cyclooxygenase activity in this process. Here, we identify the cis-acting elements
responsible for the transcriptional activation of this gene in human T lymphocytes. COX-2
promoter activity was induced upon T cell activation both in primary resting T lymphocytes
and in Jurkat cells. This induction was abrogated by inhibition of calcineurin phosphatase …