Epithelial secretory response to inflammation.

MJ Ciancio, EB Chang - Annals of the New York Academy of …, 1992 - europepmc.org
MJ Ciancio, EB Chang
Annals of the New York Academy of Sciences, 1992europepmc.org
As suggested by this and previous reviews, the neuroimmunoregulation of intestinal
secretion is a complex series of endocrine, neurocrine, paracrine and autocrine interactions
between the underlying cells in the mucosa and submucosa and the intestinal enterocyte.
Under normal conditions, the balance of each of these systems is delicately controlled, thus
allowing for normal, consistent intestinal function. However, when this finely-tuned system is
altered, such as in a diseased state, the resultant effect is an amplification of the host …
As suggested by this and previous reviews, the neuroimmunoregulation of intestinal secretion is a complex series of endocrine, neurocrine, paracrine and autocrine interactions between the underlying cells in the mucosa and submucosa and the intestinal enterocyte. Under normal conditions, the balance of each of these systems is delicately controlled, thus allowing for normal, consistent intestinal function. However, when this finely-tuned system is altered, such as in a diseased state, the resultant effect is an amplification of the host defense response. Initially thought to be protective against further insult, this local immune response, if allowed to continue uncontrollably, can exacerbate the disease process.
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