Background Neutrophils play a crucial role in the pathogenesis of acid-induced acute lung
injury. Lidocaine inhibits the function of neutrophils. This study aimed to determine whether
lidocaine attenuates acute lung injury induced by hydrochloric acid (HCl) instillation.
Methods In study 1, rabbits were divided into four groups (n= 7 each). Lung injury was
induced by intratracheal HCl (0.1 N, 3 ml/kg) in two groups. The other two groups received
saline intratracheally. Lidocaine given intravenously (2 mg/g bolus+ 2 mg x kg (-1) xh (-1) …