Therapeutic effectiveness of bisphosphonates (BP) on bone metastases in patients with
cancers including those of the breast and prostate has been well documented. However,
there are still many important questions that remain unsolved or controversial. To obtain
answers for these questions that are not readily addressed in a well-controlled manner in
clinical studies, we have developed two animal models of bone metastasis (orthotopic and
experimental). Using these models, we studied the effects of BP alone or in combination with …