[HTML][HTML] Both familial Parkinson's disease mutations accelerate α-synuclein aggregation
L Narhi, SJ Wood, S Steavenson, Y Jiang… - Journal of Biological …, 1999 - ASBMB
Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically
characterized by the presence of intracytoplasmic Lewy bodies, the major component of
which are filaments consisting of α-synuclein. Two recently identified point mutations in α-
synuclein are the only known genetic causes of PD, but their pathogenic mechanism is not
understood. Here we show that both wild type and mutant α-synuclein form insoluble fibrillar
aggregates with antiparallel β-sheet structure upon incubation at physiological temperature …
characterized by the presence of intracytoplasmic Lewy bodies, the major component of
which are filaments consisting of α-synuclein. Two recently identified point mutations in α-
synuclein are the only known genetic causes of PD, but their pathogenic mechanism is not
understood. Here we show that both wild type and mutant α-synuclein form insoluble fibrillar
aggregates with antiparallel β-sheet structure upon incubation at physiological temperature …