Overlapping T-cell epitopes in the group I allergen of Dermatophagoides species restricted by HLA-DP and HLA-DR class II molecules
The induction of IgE antibodies reactive with the group I allergen of Dermatophagoides
species (house dust mite [HDM]), which comprise a major component of the allergic immune
response in HDM-atopic individuals, is dependent on the functional activity of specific CD4+
T cells. In this report we demonstrate that for a particular HDM-atopic individual the T-cell
response to the group I allergen of Dermatophagoides pteronyssinus (Der p I) is limited to a
single region (residues 101–143) of the protein. By mapping the fine antigen specificity with …
species (house dust mite [HDM]), which comprise a major component of the allergic immune
response in HDM-atopic individuals, is dependent on the functional activity of specific CD4+
T cells. In this report we demonstrate that for a particular HDM-atopic individual the T-cell
response to the group I allergen of Dermatophagoides pteronyssinus (Der p I) is limited to a
single region (residues 101–143) of the protein. By mapping the fine antigen specificity with …