Analysis of human T cell responses to the group II allergen of Dermatophagoides species: localization of major antigenic sites
RE O'Hehir, A Verhoef, E Panagiotopoulou… - Journal of allergy and …, 1993 - Elsevier
Background: IgE antibodies reactive with the group II allergens of Dermatophagoides
species (house dust mite [HDM]) are a major component of the allergic immune response in
HDM-allergic atopic individuals. Methods: Here we demonstrate, with the use of overlapping
synthetic peptides of the group II allergen of Dermatophagoides pteronyssinus (Der pII), that
polyclonal T cells isolated from the majority of atopic HDM-allergic individuals and healthy
nonatopic control subjects respond to Der pII and that T-cell epitopes are present in all …
species (house dust mite [HDM]) are a major component of the allergic immune response in
HDM-allergic atopic individuals. Methods: Here we demonstrate, with the use of overlapping
synthetic peptides of the group II allergen of Dermatophagoides pteronyssinus (Der pII), that
polyclonal T cells isolated from the majority of atopic HDM-allergic individuals and healthy
nonatopic control subjects respond to Der pII and that T-cell epitopes are present in all …