Mitosis and apoptosis in the pituitary gland: tumour formation or hyperplasia?
A Levy - Best Practice & Research Clinical Endocrinology & …, 1999 - Elsevier
Direct analyses of trophic activity in the pituitary have been hampered by the lack of normal
human tissue to study and by the short duration of the histologically overt phases of mitosis
and apoptosis, which renders significant trophic events difficult to quantify. In rats and dogs,
pituitary cell turnover is rapid in youth, declines markedly with age and virtually ceases by
'late middle age'. Specific stimuli superimpose brief but dramatic trophic events on this active
background. There is little convincing evidence, as yet, for plasticity, ie the persistence of cell …
human tissue to study and by the short duration of the histologically overt phases of mitosis
and apoptosis, which renders significant trophic events difficult to quantify. In rats and dogs,
pituitary cell turnover is rapid in youth, declines markedly with age and virtually ceases by
'late middle age'. Specific stimuli superimpose brief but dramatic trophic events on this active
background. There is little convincing evidence, as yet, for plasticity, ie the persistence of cell …