[HTML][HTML] The chemical modification of KCa channels by carbon monoxide in vascular smooth muscle cells
The chemical modification of big conductance calcium-activated potassium (K Ca) channels
in rat tail artery smooth muscle cells by carbon monoxide (CO) was investigated using the
cell-free single channel recording technique. Exposure of the internal surface of cell
membranes to diethyl pyrocarbonate (DEPC) neither affected the characteristics of K Ca
channels nor modified the stimulatory effect of CO on K Ca channels. However, when DEPC
was applied to the external surface of cell membranes, the open probability of K Ca …
in rat tail artery smooth muscle cells by carbon monoxide (CO) was investigated using the
cell-free single channel recording technique. Exposure of the internal surface of cell
membranes to diethyl pyrocarbonate (DEPC) neither affected the characteristics of K Ca
channels nor modified the stimulatory effect of CO on K Ca channels. However, when DEPC
was applied to the external surface of cell membranes, the open probability of K Ca …