[HTML][HTML] Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: pathophysiology of biliary lipid secretion1
DQH Wang, F Lammert, B Paigen, MC Carey - Journal of lipid research, 1999 - ASBMB
The inbred C57L strain but not the AKR strain of mice carry Lith genes that determine
cholesterol gallstone susceptibility. When C57L mice are fed a lithogenic diet containing
15% fat, 1% cholesterol, and 0.5% cholic acid, gallbladder bile displays rapid cholesterol
supersaturation, mucin gel accumulation, increases in hydrophobic bile salts, and rapid
phase separation of solid and liquid crystals, all of which contribute to the high cholesterol
gallstone prevalence rates (D. QH. Wang, B. Paigen, and MC Carey. J. Lipid Res. 1997. 38 …
cholesterol gallstone susceptibility. When C57L mice are fed a lithogenic diet containing
15% fat, 1% cholesterol, and 0.5% cholic acid, gallbladder bile displays rapid cholesterol
supersaturation, mucin gel accumulation, increases in hydrophobic bile salts, and rapid
phase separation of solid and liquid crystals, all of which contribute to the high cholesterol
gallstone prevalence rates (D. QH. Wang, B. Paigen, and MC Carey. J. Lipid Res. 1997. 38 …