Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile
DQ Wang, B Paigen, MC Carey - Journal of lipid research, 1997 - ASBMB
Lith genes control susceptibility to cholesterol gallstone formation in inbred strains of mice
on a lithogenic diet containing high fat, high cholesterol and 0.5% cholic acid. Our study
defines the physical-chemical phenotypes of C57L, AKR, and (C57L x AKR) F1 mouse
gallbladder biles during 56 days on the lithogenic diet. We found enhanced cholesterol
supersaturation, accumulation of mucin gel, and larger gallbladders in all C57L and F1
mice, as well as more frequent gallstone formation in male C57L and F1 mice (80%) …
on a lithogenic diet containing high fat, high cholesterol and 0.5% cholic acid. Our study
defines the physical-chemical phenotypes of C57L, AKR, and (C57L x AKR) F1 mouse
gallbladder biles during 56 days on the lithogenic diet. We found enhanced cholesterol
supersaturation, accumulation of mucin gel, and larger gallbladders in all C57L and F1
mice, as well as more frequent gallstone formation in male C57L and F1 mice (80%) …