Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein
RPO Elferink, R Ottenhoff, M van Wijland… - Journal of lipid …, 1996 - ASBMB
Mice in which the gene for mdr2 P-glycoprotein has been disrupted have a severe
deficiency in biliary phospholipid and cholesterol secretion. We studied the relation between
mdr2 gene expression and biliary lipid secretion with emphasis on the role of bile salt
hydrophobicity. Control mice (+/+), and mice with a homozygous (-/-) or heterozygous (+/-)
disruption of the mdr2 gene, were infused with taurodeoxycholate (TDC) or
tauroursodeoxycholate (TUDC). In mdr2 (-/-) mice, virtually no phospholipids were secreted …
deficiency in biliary phospholipid and cholesterol secretion. We studied the relation between
mdr2 gene expression and biliary lipid secretion with emphasis on the role of bile salt
hydrophobicity. Control mice (+/+), and mice with a homozygous (-/-) or heterozygous (+/-)
disruption of the mdr2 gene, were infused with taurodeoxycholate (TDC) or
tauroursodeoxycholate (TUDC). In mdr2 (-/-) mice, virtually no phospholipids were secreted …