Adaptation to low-protein diets in renal failure: leucine turnover and nitrogen balance.
TH Goodship, WE Mitch, RA Hoerr… - Journal of the …, 1990 - journals.lww.com
In normal subjects, short to intermediate responses to dietary protein restriction include
decreased amino acid oxidation and protein degradation plus increased utilization of amino
acids for protein synthesis; these responses are activated to improve amino acid utilization
and nitrogen balance. To assess whether chronic renal failure (CRF) impairs the adaptive
responses to a low-protein diet, we measured nitrogen balance and the kinetics of infused L-
(15N, 1-13C) leucine during fasting and feeding. In six adult CRF and four control (C) …
decreased amino acid oxidation and protein degradation plus increased utilization of amino
acids for protein synthesis; these responses are activated to improve amino acid utilization
and nitrogen balance. To assess whether chronic renal failure (CRF) impairs the adaptive
responses to a low-protein diet, we measured nitrogen balance and the kinetics of infused L-
(15N, 1-13C) leucine during fasting and feeding. In six adult CRF and four control (C) …