Proinflammatory cytokines and CD40 ligand enhance cross-presentation and cross-priming capability of human dendritic cells internalizing apoptotic cancer cells
TK Hoffmann, N Meidenbauer… - Journal of …, 2001 - journals.lww.com
Human monocyte-derived dendritic cells (DC) can ingest apoptotic tumor cells (ATC) and
present tumor-associated antigens (TAA) to T cells, leading to the generation of tumor-
specific cytotoxic effector cells (Cancer Res 2000; 60: 3542–9). To further augment antitumor
effector cell responses, attempts were made to modify antigen presentation and cross-
priming of T cells by DC fed with ATC. Proinflammatory cytokines (PC), CD40 ligand
(CD40L) and/or interferon-γ (IFN-γ) were found to markedly enhance the immunogenicity of …
present tumor-associated antigens (TAA) to T cells, leading to the generation of tumor-
specific cytotoxic effector cells (Cancer Res 2000; 60: 3542–9). To further augment antitumor
effector cell responses, attempts were made to modify antigen presentation and cross-
priming of T cells by DC fed with ATC. Proinflammatory cytokines (PC), CD40 ligand
(CD40L) and/or interferon-γ (IFN-γ) were found to markedly enhance the immunogenicity of …