[HTML][HTML] Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics
WJ Sanders, EJ Gordon, O Dwir, PJ Beck… - Journal of Biological …, 1999 - ASBMB
Synthetic carbohydrate and glycoprotein mimics displaying sulfated saccharide residues
have been assayed for their L-selectin inhibitory properties under static and flow conditions.
Polymers displaying the L-selectin recognition epitopes 3′, 6-disulfo Lewis x (Glc)(3-O-SO
3-Galβ1α4 (Fucα1α3)-6-O-SO 3-Glcβ-OR) and 3′, 6′-disulfo Lewis x (Glc)(3, 6-di-O-SO 3-
Galβ1α4 (Fucα1α3) Glcβ-OR) both inhibit L-selectin binding to heparin under static, cell-free
binding conditions with similar efficacies. Under conditions of shear flow, however, only the …
have been assayed for their L-selectin inhibitory properties under static and flow conditions.
Polymers displaying the L-selectin recognition epitopes 3′, 6-disulfo Lewis x (Glc)(3-O-SO
3-Galβ1α4 (Fucα1α3)-6-O-SO 3-Glcβ-OR) and 3′, 6′-disulfo Lewis x (Glc)(3, 6-di-O-SO 3-
Galβ1α4 (Fucα1α3) Glcβ-OR) both inhibit L-selectin binding to heparin under static, cell-free
binding conditions with similar efficacies. Under conditions of shear flow, however, only the …
