Solvolytic desulfation of glycosaminoglycuronan sulfates with dimethyl sulfoxide containing water or methanol
K Nagasawa, Y Inoue, T Kamata - Carbohydrate Research, 1977 - Elsevier
A solvolytic desulfation of glycosaminoglycuronan sulfates was developed by treatment of
their pyridinium salts with dimethyl sulfoxide containing 10% of water or methanol at 80–
100°. Chemical and physical studies showed that the solvolytic desulfation is a useful
method applicable to all the known glycosaminoglycuronan sulfates without producing
depolymerization or unfavorable chemical changes in the polysaccharide molecules. An
almost completely desulfated, N-acetylated heparin (S: 0.12) was obtained by treatment of …
their pyridinium salts with dimethyl sulfoxide containing 10% of water or methanol at 80–
100°. Chemical and physical studies showed that the solvolytic desulfation is a useful
method applicable to all the known glycosaminoglycuronan sulfates without producing
depolymerization or unfavorable chemical changes in the polysaccharide molecules. An
almost completely desulfated, N-acetylated heparin (S: 0.12) was obtained by treatment of …