Selectins play a major role in the inflammatory reaction by initiating neutrophil attachment to
activated vascular endothelium. Some heparin preparations can interact with L-and P-
selectin; however, the determinants required for inhibiting selectin-mediated cell adhesion
have not yet been characterized. We now report that carboxyl-reduced and sulfated heparin
(prepared by chemical modifications of porcine intestinal mucosal heparin leading to the
replacement of carboxylates by O-sulfate groups) and trestatin A sulfate (obtained by …