[HTML][HTML] Expression of recombinant HLA-DR2 molecules: Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the …
A Kalandadze, M Galleno, L Foncerrada… - Journal of Biological …, 1996 - ASBMB
Major histocompatibility complex (MHC) class II molecules are membrane-anchored
heterodimers that present peptides on the surface of antigen presenting cells to T cells.
Soluble HLA-DR2 molecules were expressed for structural and functional characterization of
the MHC/peptide/T cell receptor recognition unit. The α and β; chains of DR2 (encoded by
the DRA, DRB1* 1501 genes) did not assemble in mammalian or insect cell lines when the
transmembrane regions of one or both chains were truncated. The hydrophobic …
heterodimers that present peptides on the surface of antigen presenting cells to T cells.
Soluble HLA-DR2 molecules were expressed for structural and functional characterization of
the MHC/peptide/T cell receptor recognition unit. The α and β; chains of DR2 (encoded by
the DRA, DRB1* 1501 genes) did not assemble in mammalian or insect cell lines when the
transmembrane regions of one or both chains were truncated. The hydrophobic …