Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous
system (CNS) which can be characterized clinically by a remitting–relapsing or a chronic
progressive course. There is a striking similarity between the clinical and histopathological
features of MS and the experimentally induced disease, experimental autoimmune
encephalomyelitis (EAE). Induced by the injection of myelin basic protein (MBP) and
adjuvants, EAE is characterized by clinical neurologic signs of paralysis and histopathologic …