Localization of estrogen receptor alpha (ERα) in pyramidal neurons of the developing rat hippocampus

DT Solum, RJ Handa - Developmental Brain Research, 2001 - Elsevier
During development, estrogen has a variety of effects on morphological, biochemical and
electrophysiological properties of hippocampal neurons. Correspondingly, estrogen
receptor (ER) binding and mRNA increase transiently in the developing hippocampus. In
this study, we used immunocytochemistry to determine the localization of the ERα subtype in
the developing rat hippocampus. Nuclear staining was present in pyramidal cells and some
interneurons of the CA1 and CA3 regions of the developing rat hippocampus. Little or no …