Estrogen accelerates immune complex glomerulonephritis but ameliorates T cell-mediated vasculitis and sialadenitis in autoimmune MRL lpr/lpr mice
H Carlsten, N Nilsson, R Jonsson, K Bäckman… - Cellular …, 1992 - Elsevier
Estrogen is known to influence immune responses in healthy subjects in a dichotomous
fashion. Thus, in number of previous studies we and others have demonstrated that B cell
activities are augmented after exposure to estrogen whereas T cell reactivity is suppressed.
Furthermore, it has been shown that this hormone has significant impact on the course of
certain human and experimental autoimmune diseases. In this study we report that treatment
with physiological doses of estradiol exerts dichotomous effects on different manifestations …
fashion. Thus, in number of previous studies we and others have demonstrated that B cell
activities are augmented after exposure to estrogen whereas T cell reactivity is suppressed.
Furthermore, it has been shown that this hormone has significant impact on the course of
certain human and experimental autoimmune diseases. In this study we report that treatment
with physiological doses of estradiol exerts dichotomous effects on different manifestations …