Hexosamines as mediators of nutrient sensing and regulation in diabetes
DA McClain - Journal of Diabetes and its Complications, 2002 - Elsevier
High concentrations of glucose induce insulin resistance, impair insulin secretion, and affect
hepatic glucose production in a manner that mirrors Type 2 diabetes, and hexosamines
mimic many of these effects. This has led to the hypothesis that cells use hexosamine flux as
a glucose-and satiety-sensing pathway. The hexosamine hypothesis for glucose sensing
has been validated by overexpressing the rate-limiting enzyme for hexosamine synthesis,
glutamine: fructose-6-phosphate amidotransferase (GFA) in several tissues including …
hepatic glucose production in a manner that mirrors Type 2 diabetes, and hexosamines
mimic many of these effects. This has led to the hypothesis that cells use hexosamine flux as
a glucose-and satiety-sensing pathway. The hexosamine hypothesis for glucose sensing
has been validated by overexpressing the rate-limiting enzyme for hexosamine synthesis,
glutamine: fructose-6-phosphate amidotransferase (GFA) in several tissues including …
