[HTML][HTML] Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization …
YZ Lin, SY Yao, RA Veach, TR Torgerson… - Journal of Biological …, 1995 - ASBMB
To control agonist-induced nuclear translocation of transcription factor κB (NF-κB) in intact
cells, cell-permeable synthetic peptides were devised. Their import into intact cells was
dependent on a hydrophobic region selected from the signal peptide sequences and was
verified by their inaccessibility to extracellular proteases and by confocal laser scanning
microscopy. When a cell-permeable peptide carried a functional cargo representing the
nuclear localization sequence of NF-κB p50, it inhibited in a concentration-dependent …
cells, cell-permeable synthetic peptides were devised. Their import into intact cells was
dependent on a hydrophobic region selected from the signal peptide sequences and was
verified by their inaccessibility to extracellular proteases and by confocal laser scanning
microscopy. When a cell-permeable peptide carried a functional cargo representing the
nuclear localization sequence of NF-κB p50, it inhibited in a concentration-dependent …