[HTML][HTML] Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop
Gonadotropin receptors are members of the seven-transmembrane (TM) receptor family.
Several point mutations in TM V and VI and the intracellular loop 3 (i3) have been identified
in the luteinizing hormone (LH) receptor gene, leading to constitutive activation of the
receptor. Because gonadotropin receptors are highly conserved, we mutated the follicle-
stimulating hormone (FSH) receptor at the corresponding amino acids. However, the FSH
receptor mutants showed minimal increases in basal cAMP production. Taking advantage of …
Several point mutations in TM V and VI and the intracellular loop 3 (i3) have been identified
in the luteinizing hormone (LH) receptor gene, leading to constitutive activation of the
receptor. Because gonadotropin receptors are highly conserved, we mutated the follicle-
stimulating hormone (FSH) receptor at the corresponding amino acids. However, the FSH
receptor mutants showed minimal increases in basal cAMP production. Taking advantage of …