[HTML][HTML] Acute graft-vs-host disease: pathobiology and management
H Goker, IC Haznedaroglu, NJ Chao - Experimental hematology, 2001 - Elsevier
Acute graft-vs-host disease (GVHD) is a major obstacle to safe allogeneic hematopoietic
stem cell transplantation (HSCT), leading to a significant morbidity and mortality. GVHD
occurs when transplanted donor T lymphocytes react to foreign host cells. It causes a wide
variety of host tissue injuries. This review focuses on the pathobiological basis, clinical
aspects, and current management strategies of acute GVHD. Afferent phase of acute GVHD
starts with myeloablative conditioning, ie, before the infusion of the graft. Total-body …
stem cell transplantation (HSCT), leading to a significant morbidity and mortality. GVHD
occurs when transplanted donor T lymphocytes react to foreign host cells. It causes a wide
variety of host tissue injuries. This review focuses on the pathobiological basis, clinical
aspects, and current management strategies of acute GVHD. Afferent phase of acute GVHD
starts with myeloablative conditioning, ie, before the infusion of the graft. Total-body …