[HTML][HTML] The pancreatitis-associated protein I promoter allows targeting to the pancreas of a foreign gene, whose expression is up-regulated during pancreatic …
NJ Dusetti, S Vasseur, EM Ortiz, H Romeo… - Journal of Biological …, 1997 - ASBMB
The pancreatitis-associated protein I (PAP I) is a pancreatic secretory protein expressed in
pancreas during acute pancreatitis but not in the healthy pancreas. The promoter of the PAP
I gene thus represents a potential candidate to drive expression of therapeutic molecules to
the diseased pancreas. In this work, we have constructed recombinant adenoviruses
harboring the chloramphenicol acetyltransferase (CAT) gene driven by several fragments of
the PAP I promoter and have characterized their properties in vitro and in vivo. In vitro …
pancreas during acute pancreatitis but not in the healthy pancreas. The promoter of the PAP
I gene thus represents a potential candidate to drive expression of therapeutic molecules to
the diseased pancreas. In this work, we have constructed recombinant adenoviruses
harboring the chloramphenicol acetyltransferase (CAT) gene driven by several fragments of
the PAP I promoter and have characterized their properties in vitro and in vivo. In vitro …
