Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia
ES Connolly Jr, CJ Winfree, DM Stern… - …, 1996 - journals.lww.com
Abstract THE RECENT AVAILABILITY of transgenic mice has led to a burgeoning number of
reports describing the effects of specific gene products on the pathophysiology of stroke.
Although focal cerebral ischemia models in rats have been well described, descriptions of a
murine model of middle cerebral artery occlusion are scant and sources of potential
experimental variability remain undefined. We hypothesized that slight technical
modifications would produce widely discrepant results in a murine model of stroke and that …
reports describing the effects of specific gene products on the pathophysiology of stroke.
Although focal cerebral ischemia models in rats have been well described, descriptions of a
murine model of middle cerebral artery occlusion are scant and sources of potential
experimental variability remain undefined. We hypothesized that slight technical
modifications would produce widely discrepant results in a murine model of stroke and that …