Stimulation of B-cell progenitors by cloned murine interleukin-7
AE Namen, S Lupton, K Hjerrild, J Wignall… - Nature, 1988 - nature.com
AE Namen, S Lupton, K Hjerrild, J Wignall, DY Mochizuki, A Schmierer, B Mosley, CJ March…
Nature, 1988•nature.comThe events involved in the commitment and development of lymphoid lineage cells are
poorly understood. We have used a recently described long-term culture system1 to
establish a bioassay that can detect a novel growth factor capable of stimulating the
proliferation of lymphoid progenitors2. Using direct expression in mammalian cells we have
isolated a complementary DNA clone encoding this novel haematopoietic growth factor,
designated interleukin-7.
poorly understood. We have used a recently described long-term culture system1 to
establish a bioassay that can detect a novel growth factor capable of stimulating the
proliferation of lymphoid progenitors2. Using direct expression in mammalian cells we have
isolated a complementary DNA clone encoding this novel haematopoietic growth factor,
designated interleukin-7.
Abstract
The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system1 to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors2. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.
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