[HTML][HTML] The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor∗
SM Zurawski, P Chomarat, O Djossou, C Bidaud… - Journal of Biological …, 1995 - ASBMB
Interleukin (IL)-13 elicits a subset of the biological activities of the related IL-4. The basis of
this functional similarity is that their specific cell-surface receptors (called IL-13R and IL-4R)
are distinct, yet are complex and share a common subunit (s). The IL-4R primary binding
subunit (called IL-4Rα) does not by itself bind IL-13. We show that the ability of IL-13 to
partially compete for IL-4 binding to some human cell types depended on co-expression of
IL-4R and IL-13R. However, IL-13 binding was always associated with IL-4 binding …
this functional similarity is that their specific cell-surface receptors (called IL-13R and IL-4R)
are distinct, yet are complex and share a common subunit (s). The IL-4R primary binding
subunit (called IL-4Rα) does not by itself bind IL-13. We show that the ability of IL-13 to
partially compete for IL-4 binding to some human cell types depended on co-expression of
IL-4R and IL-13R. However, IL-13 binding was always associated with IL-4 binding …