[HTML][HTML] Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation: evidence for an interleukin-13-driven phosphatidylinositol 3 …
A combination of the pro-inflammatory cytokines interleukin (IL)-1α, interferon (IFN)-γ, and
tumor necrosis factor (TNF)-α induces nitric oxide synthase mRNA expression and nitric
oxide (NO) generation in the human colon carcinoma cell line HT-29. This can be inhibited
by pretreatment with IL-13 via a phosphatidylinositol (PI) 3-kinase-dependent mechanism
(Wright, K., Ward, SG, Kolios, G., and Westwick, J.(1997) J. Biol. Chem. 272, 12626–12633).
Since NO has been implicated in regulating mechanisms leading to cell death, while …
tumor necrosis factor (TNF)-α induces nitric oxide synthase mRNA expression and nitric
oxide (NO) generation in the human colon carcinoma cell line HT-29. This can be inhibited
by pretreatment with IL-13 via a phosphatidylinositol (PI) 3-kinase-dependent mechanism
(Wright, K., Ward, SG, Kolios, G., and Westwick, J.(1997) J. Biol. Chem. 272, 12626–12633).
Since NO has been implicated in regulating mechanisms leading to cell death, while …
