Prostaglandin as an effective antirejection therapy in rat renal allograft recipients
TB STROM, CB CARPENTER - Transplantation, 1983 - journals.lww.com
TB STROM, CB CARPENTER
Transplantation, 1983•journals.lww.comBecame adenylate cyclase activators such as prosta-glandin E 1 elevate lymphocytic cyclic
AMP and inhibit T cell proliferation and the effector function of cytotoxic T cells in vitro, we
tested the efficacy of 15 (S)-15-methyl prostaglandin E 1, a prostaglandin derivative with a
prolonged biologic half-life. Treatment with this agent resulted in a near complete protection
of renal grafts from immunologic damage, despite withholding therapy until day 4 following
transplantation.
AMP and inhibit T cell proliferation and the effector function of cytotoxic T cells in vitro, we
tested the efficacy of 15 (S)-15-methyl prostaglandin E 1, a prostaglandin derivative with a
prolonged biologic half-life. Treatment with this agent resulted in a near complete protection
of renal grafts from immunologic damage, despite withholding therapy until day 4 following
transplantation.
Abstract
Became adenylate cyclase activators such as prosta-glandin E 1 elevate lymphocytic cyclic AMP and inhibit T cell proliferation and the effector function of cytotoxic T cells in vitro, we tested the efficacy of 15 (S)-15-methyl prostaglandin E 1, a prostaglandin derivative with a prolonged biologic half-life. Treatment with this agent resulted in a near complete protection of renal grafts from immunologic damage, despite withholding therapy until day 4 following transplantation.
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